Early morning run-training results in enhanced endurance performance adaptations in mice.

ABSTRACT: Time-of-day differences in acute exercise performance in mice are well established with late active phase (afternoon) runners exhibiting significantly greater endurance performance compared to early active phase (morning) runners. In this study, we asked if performance adaptations would be different when training for 6 weeks at two different times of day, and if this corresponds to steady state changes in the phase of peripheral tissue clocks. To address these questions, we endurance trained female PER2::Luciferase mice, at the same relative workload, either in the morning, at ZT13, or in the afternoon, at ZT22. Then, after training, we recorded luminescence from tissues of PER2::Luciferase mice to report timing of tissue clocks in several peripheral tissues. After 6 weeks, we found that b

SUBMITTER: Hesketh SJ 

PROVIDER: S-EPMC10541096 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature