Polymorphic Structure Determination of the Macrocyclic Drug Paritaprevir by MicroED.

ABSTRACT: Paritaprevir is an orally bioavailable, macrocyclic drug used for treating chronic Hepatitis C virus infection. Its structures had been elusive to the public until recently when one of the crystal forms was solved by MicroED. In this work, we report the MicroED structures of two distinct polymorphic crystal forms of paritaprevir from the same experiment. The different polymorphs show conformational changes in the macrocyclic core, as well as the cyclopropylsulfonamide and methylpyrazinamide substituents. Molecular docking shows that one of the conformations fits well into the active site pocket of the NS3/4A serine protease target, and can interact with the pocket and catalytic triad via hydrophobic interactions and hydrogen bonds. These results can provide further insight for optimization

SUBMITTER: Bu G 

PROVIDER: S-EPMC10541134 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature