A novel nomogram for identifying high-risk patients among active surveillance candidates with papillary thyroid microcarcinoma.

ABSTRACT:

Objective

Active surveillance (AS) has been recommended as the first-line treatment strategy for low-risk (LR) papillary thyroid microcarcinoma (PTMC) according to the guidelines. However, preoperative imaging and fine-needle aspiration could not rule out a small group of patients with aggressive PTMC with large-volume lymph node micro-metastasis, extrathryoidal invasion to surrounding soft tissue, or high-grade malignancy from the AS candidates.

Methods

Among 2,809 PTMC patients, 2,473 patients were enrolled in this study according to the inclusion criteria. Backward stepwise multivariate logistic regression analysis was used to filter clinical characteristics and ultrasound features to identify independent predictors of high-risk (HR) patients. A nomogram was developed and

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10541211 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature