Retinal inflammation in murine models of type 1 and type 2 diabetes with diabetic retinopathy.

ABSTRACT:

Aims/hypothesis

The loss of pericytes surrounding the retinal vasculature in early diabetic retinopathy underlies changes to the neurovascular unit that lead to more destructive forms of the disease. However, it is unclear which changes lead to loss of retinal pericytes. This study investigated the hypothesis that chronic increases in one or more inflammatory factors mitigate the signalling pathways needed for pericyte survival.

Methods

Loss of pericytes and levels of inflammatory markers at the mRNA and protein levels were investigated in two genetic models of diabetes, Ins2^Akita/+ (a model of type 1 diabetes) and Lepr^db/db (a model of type 2 diabetes), at early stages of diabetic retinopathy. In addition, changes that accompany gliosis and the retinal

SUBMITTER: Dharmarajan S 

PROVIDER: S-EPMC10541343 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature