Updating approach for lexicographic optimization-based planning to improve cervical cancer plan quality.

ABSTRACT:

Background

To investigate the capability of a not-yet commercially available fully automated lexicographic optimization (LO) planning algorithm, called mCycle (Elekta AB, Stockholm, Sweden), to further improve the plan quality of an already-validated Wish List (WL) pushing on the organs-at-risk (OAR) sparing without compromising target coverage and plan delivery accuracy.

Material and methods

Twenty-four mono-institutional consecutive cervical cancer Volumetric-Modulated Arc Therapy (VMAT) plans delivered between November 2019 and April 2022 (50 Gy/25 fractions) have been retrospectively selected. In mCycle the LO planning algorithm was combined with the a-priori multi-criterial optimization (MCO). Two versions of WL have been defined to reproduce manual plans (WL01), and to

SUBMITTER: Caricato P 

PROVIDER: S-EPMC10541351 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature