Dataset Information

Conversion of the bronchial tree into a conforming electrode to ablate the lung nodule in a porcine model.

ABSTRACT:

Background

Radiofrequency ablation (RFA) is one of the treatment options for lung nodules. However, the need for exact delivery of the rigid metal electrode into the center of the target mass often leads to complications or suboptimal results. To overcome these limitations, a concept of conforming electrodes using a flexible material has been tested in this study.

Methods

A bronchoscopy-guided RFA (CAROL) under a temperature-controlled mode was tested in in-vivo and ex-vivo porcine lungs. Gallium-based liquid metal was used for turning the bronchial tree into temporary RF electrodes. A customized bronchoscopy-guided balloon-tipped guiding catheter (CAROL catheter) was used to make the procedure feasible under fluoroscopy imaging guidance. The computer simulation was also performed to gain further insight into the ablation results. Safety was also assessed including the liquid metal remaining in the body.

Results

The bronchial electrode injected from the CAROL catheter was able to turn the target site bronchial air pipe into a temporally multi-tined RF electrode. The mean volume of Gallium for each effective CAROL was 0.46 ± 0.47 ml. The ablation results showed highly efficacious and consistent results, especially in the peripheral lung. Most bronchial electrodes were also retrieved by either bronchoscopic suction immediately after the procedure or by natural expectoration thereafter. The liquid metal used in these experiments did not have any significant safety issues. Computer simulation also supports these results.

Conclusion

The CAROL ablation was very effective and safe in porcine lungs showing encouraging potential to overcome the conventional approaches.

SUBMITTER: Shah IA

PROVIDER: S-EPMC10541426 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Publications

Conversion of the bronchial tree into a conforming electrode to ablate the lung nodule in a porcine model.

Shah Izaz Ali IA Seol Hee Yun HY Cho Youngdae Y Ji Wonjun W Seo Jaeyoung J Lee Cheolmin C Chon Min-Ku MK Shin Donghoon D Kim Justin H JH Choo Ki-Seok KS Park Junhui J Kim Juhyung J Yoo Hyoungsuk H Kim June-Hong JH

Communications medicine 20230929 1

<h4>Background</h4>Radiofrequency ablation (RFA) is one of the treatment options for lung nodules. However, the need for exact delivery of the rigid metal electrode into the center of the target mass often leads to complications or suboptimal results. To overcome these limitations, a concept of conforming electrodes using a flexible material has been tested in this study.<h4>Methods</h4>A bronchoscopy-guided RFA (CAROL) under a temperature-controlled mode was tested in in-vivo and ex-vivo porcin ...[more]

PMID: 37775526

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Project description:To investigate the effect of the bronchial tree on the accuracy of biomechanical-based deformable image registration of human lungs.Three dimensional finite element models have been developed using four dimensional computed tomography image data of ten lung cancer patients. Each model is built of a body, left and right lungs, tumor, and bronchial trees. Triangular shell elements are used for the bronchial trees while tetrahedral elements are used for other components. Hyperelastic material properties based on experimental investigation on human lungs are used for the lung parenchyma. Different material properties are assigned for the bronchial tree using five values for the modulus of elasticity of 0.01, 0.12, 0.5, 10, and 18 MPa. Lungs are modeled to slide inside chest cavities by applying frictionless contact surfaces between each lung and corresponding chest cavity. The accuracy of the models is examined using an average of 40 bronchial bifurcation points identified on inhale and exhale images. Relative accuracy is evaluated by comparing the displacement of all nodes within the lungs as well as the dosimetric difference at the exhale position predicted by the model.There is no significant effect of bronchial tree on the model accuracy based on the bifurcation points analysis. However, on the local level, using an average of 38 000 nodes, there is a maximum difference of 8.5 mm in the deformation of the bronchial trees, as the modulus of elasticity of the bronchial trees increases from 0.01 to 18 MPa; however, more than 96% of nodes are within a 2.5 mm difference in each direction. The average dose difference at the predicted exhale position is less than 35 cGy between the models.The bronchial tree has little effect on the global deformation and the accuracy of deformable image registration of lungs. Hence, the homogenous model is a reasonable assumption. Since there are some local deformation differences between nodes as the material properties of the bronchial tree change that may affect the accuracy of dosimetric results, heterogeneity may be required for a smaller scale modeling of lungs.

Dataset Information

Conversion of the bronchial tree into a conforming electrode to ablate the lung nodule in a porcine model.

Background

Methods

Results

Conclusion

Publications

Conversion of the bronchial tree into a conforming electrode to ablate the lung nodule in a porcine model.

Similar Datasets

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