Glycogen synthase kinase 3 controls T-cell exhaustion by regulating NFAT activation.

ABSTRACT: Cellular immunity mediated by CD8⁺ T cells plays an indispensable role in bacterial and viral clearance and cancers. However, persistent antigen stimulation of CD8⁺ T cells leads to an exhausted or dysfunctional cellular state characterized by the loss of effector function and high expression of inhibitory receptors during chronic viral infection and in tumors. Numerous studies have shown that glycogen synthase kinase 3 (GSK3) controls the function and development of immune cells, but whether GSK3 affects CD8⁺ T cells is not clearly elucidated. Here, we demonstrate that mice with deletion of Gsk3α and Gsk3β in activated CD8⁺ T cells (DKO) exhibited decreased CTL differentiation and effector function during acute and chronic viral infection. In ad

SUBMITTER: Fu Y 

PROVIDER: S-EPMC10541428 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature