NAD⁺ salvage governs the immunosuppressive capacity of mesenchymal stem cells.

ABSTRACT: Mesenchymal stem/stromal cells (MSCs) possess robust immunoregulatory functions and are promising therapeutics for inflammatory disorders. This capacity is not innate but is activated or 'licensed' by inflammatory cytokines. The licensing mechanism remains unclear. Here, we examined whether inflammatory cytokines metabolically reprogrammed MSCs to confer this immunoregulatory capacity. In response to stimulation by inflammatory cytokines, MSCs exhibited a dramatic increase in the consumption of glucose, which was accompanied by an enhanced use of nicotinamide adenine dinucleotide (NAD⁺) and increased expression of nicotinamide phosphoribosyltransferase (NAMPT), a central enzyme in the salvage pathway for NAD⁺ production. When NAD⁺ synthesis was blocked by i

SUBMITTER: Fang J 

PROVIDER: S-EPMC10541442 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature