Incident cancers attributable to using opium and smoking cigarettes in the Golestan cohort study.

ABSTRACT:

Background

Opium consumption has recently been identified as a carcinogen, but the impact of opium use on cancer burden is unknown. We aimed to evaluate the fraction of cancers that could be attributed to opium use alone and in combination with cigarette smoking in a region where opium is widely used.

Methods

50,045 Iranian adults were recruited to this prospective cohort study between 2004 and 2008 and were followed through January 2022. We assessed the association between using opium and/or cigarette smoking and various cancers using proportional hazards regression models. We then calculated population attributable fractions (PAFs) for all cancers and for groups of cancers causally linked to opium and cigarette smoking.

Findings

Of the total participants, 8% only us

SUBMITTER: Alcala K 

PROVIDER: S-EPMC10541463 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature