Mood instability and low back pain: a mendelian randomization study.

ABSTRACT:

Objective

Low back pain is a prevalent and debilitating condition worldwide, with significant implications for individuals' quality of life and productivity. The aim of this study was to assess the relationship between mood instability and the risk of developing chronic low back pain, using a rigorously designed mendelian randomization methodology.

Method

The study incorporated both univariate and multivariate mendelian randomization to analysis the causal relationship between mood instability and the risk of developing chronic low back pain. The data on mood instability from the Integrative Epidemiology Unit (IEU) opened Genome-Wide Association Studies (GWAS) project (IEU-opened GWAS project). Data on low back pain were collected from two sources: One source is the IEU open

SUBMITTER: Liu R 

PROVIDER: S-EPMC10541504 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature