AgRP neuron activity promotes associations between sensory and nutritive signals to guide flavor preference.

ABSTRACT:

Objective

The learned associations between sensory cues (e.g., taste, smell) and nutritive value (e.g., calories, post-ingestive signaling) of foods powerfully influences our eating behavior [1], but the neural circuits that mediate these associations are not well understood. Here, we examined the role of agouti-related protein (AgRP)-expressing neurons - neurons which are critical drivers of feeding behavior [2; 3] - in mediating flavor-nutrient learning (FNL).

Methods

Because mice prefer flavors associated with AgRP neuron activity suppression [4], we examined how optogenetic stimulation of AgRP neurons during intake influences FNL, and used fiber photometry to determine how endogenous AgRP neuron activity tracks associations between flavors and nutrients.

Results

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SUBMITTER: Nyema NT 

PROVIDER: S-EPMC10541598 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature