Identification of SNP markers for canine mammary gland tumours in females based on a genome-wide association study - preliminary results.

ABSTRACT:

Introduction

The development of genetic research over recent decades has enabled the discovery of new genetic markers, such as single nucleotide polymorphisms (SNPs). This, as well as the full sequencing of the dog genome, has enabled genome-wide association studies (GWAS) to be used in the search for genetic causes of canine mammary tumours (CMTs).

Material and methods

Genotypic data containing 175,000 SNPs, which had been obtained using the Illumina CanineHD BeadChip microarray technique, were available for analysis in this study. The data concerned 118 bitches, including 36 animals with CMT, representing various breeds and age groups. Statistical analysis was performed in two steps: quality control of genotyping data and genome-wide association analysis based on dominant,

SUBMITTER: Mucha A 

PROVIDER: S-EPMC10541661 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature