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High triglyceride-glucose (TyG) index is associated with poor prognosis of heart failure with preserved ejection fraction.


ABSTRACT:

Background

The impact of insulin resistance on the prognosis of heart failure with preserved ejection fraction (HFpEF) remains unknown. This study aimed to investigate the association between the triglyceride-glucose (TyG) index, an easily calculated marker of insulin resistance, and the long-term prognosis of HFpEF.

Methods

A total of 823 patients with HFpEF were enrolled in the study. The TyG index was determined using the formula ln(fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). The primary endpoint was all-cause death. The secondary endpoints were cardiovascular (CV) death and heart failure (HF) rehospitalization. Restricted cubic spline, multivariate Cox proportional hazard models, and competing risk models were used for analyses.

Results

During a median follow-up period of 3.16 years, 147 (17.8%) all-cause deaths, 139 (16.8%) CV deaths, and 222 (27.0%) HF rehospitalizations occurred. Restricted cubic spline analysis revealed a J-shaped association between the TyG index and the mortality and rehospitalization rates. In the multivariate Cox proportional hazard models, compared with those in the lowest TyG index tertile, patients in the highest tertile exhibited the greatest susceptibility to all-cause death (HR 1.53, 95% CI 1.19-1.98) and CV death (HR 1.52, 95% CI 1.19-1.96). In the competing risk model, a significant association between the TyG index and HF rehospitalization was observed (HR 1.31, 95% CI, 1.07-1.61).

Conclusion

A high TyG index is associated with an increased risk of mortality and rehospitalization in patients with HFpEF. The TyG index may serve as a promising prognostic marker for patients with HFpEF.

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC10541699 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Publications

High triglyceride-glucose (TyG) index is associated with poor prognosis of heart failure with preserved ejection fraction.

Zhou Qing Q   Yang Jie J   Tang Hongyi H   Guo Zexuan Z   Dong Wenyue W   Wang Yiting Y   Meng Xiangbin X   Zhang Kuo K   Wang Wenyao W   Shao Chunli C   Hua Xinwei X   Tang Yi-Da YD  

Cardiovascular diabetology 20230929 1


<h4>Background</h4>The impact of insulin resistance on the prognosis of heart failure with preserved ejection fraction (HFpEF) remains unknown. This study aimed to investigate the association between the triglyceride-glucose (TyG) index, an easily calculated marker of insulin resistance, and the long-term prognosis of HFpEF.<h4>Methods</h4>A total of 823 patients with HFpEF were enrolled in the study. The TyG index was determined using the formula ln(fasting triglycerides [mg/dL] × fasting gluco  ...[more]

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