High triglyceride-glucose (TyG) index is associated with poor prognosis of heart failure with preserved ejection fraction.

ABSTRACT:

Background

The impact of insulin resistance on the prognosis of heart failure with preserved ejection fraction (HFpEF) remains unknown. This study aimed to investigate the association between the triglyceride-glucose (TyG) index, an easily calculated marker of insulin resistance, and the long-term prognosis of HFpEF.

Methods

A total of 823 patients with HFpEF were enrolled in the study. The TyG index was determined using the formula ln(fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). The primary endpoint was all-cause death. The secondary endpoints were cardiovascular (CV) death and heart failure (HF) rehospitalization. Restricted cubic spline, multivariate Cox proportional hazard models, and competing risk models were used for analyses.

Results

During a me

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC10541699 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature