Predictive factors for survival in borderline resectable and locally advanced pancreatic cancer: are these really two different entities?

ABSTRACT:

Background

The treatment of borderline resectable (BR) and locally advanced (LA) pancreatic ductal adenocarcinoma (PDAC) has evolved with a wider application of neoadjuvant chemotherapy (NACHT). The aim of this study was to identify predictive factors for survival in BR and LA PDAC.

Methods

Clinicopathologic data of patients with BR and LA PDAC who underwent surgical exploration between January 2011 and June 2021 were retrospectively collected. Survival from the date of surgery was estimated using the Kaplan-Meier method. Simple and multiple Cox proportional hazards models were fitted to identify factors associated with survival. Surgical resection was analyzed in combination with the involvement of lymph nodes as this last was only known after a formal resection.

Results

SUBMITTER: de Carvalho LFA 

PROVIDER: S-EPMC10541717 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature