Translational assessment of a DATA-functionalized FAP inhibitor with facile ⁶⁸Ga-labeling at room temperature.

ABSTRACT:

Purpose

The present study aims at evaluating the preclinical and the clinical performance of [⁶⁸Ga]Ga-DATA^5m.SA.FAPi, which has the advantage to be labeled with gallium-68 at room temperature.

Methods

[⁶⁸Ga]Ga-DATA^5m.SA.FAPi was assessed in vitro on FAP-expressing stromal cells, followed by biodistribution and in vivo imaging on prostate and glioblastoma xenografts. Moreover, the clinical assessment of [⁶⁸Ga]Ga-DATA^5m.SA.FAPi was conducted on six patients with prostate cancer, aiming on investigating, biodistribution, biokinetics, and determining tumor uptake.

Results

[⁶⁸Ga]Ga-DATA^5m.SA.FAPi is quantitatively prepared in an instant kit-type version at room temperature. It demonstra

SUBMITTER: Escudero-Castellanos A 

PROVIDER: S-EPMC10541845 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature