Cystine/glutamate antiporter System x_c^- deficiency impairs insulin secretion in mice.

ABSTRACT:

Aims/hypothesis

Glutamate-induced cytotoxicity (excitotoxicity) has been detected in pancreatic beta cells. The cystine/glutamate antiporter System x_c^- exports glutamate to the extracellular space and is therefore implicated as driving excitotoxicity. As of yet, it has not been investigated whether System x_c^- contributes to pancreatic islet function.

Methods

This study describes the implications of deficiency of System x_c^- on glucose metabolism in both constitutive and myeloid cell-specific knockout mice using metabolic tests and diet-induced obesity. Pancreatic islets were isolated and analysed for beta cell function, glutathione levels and ER stress.

Results

Constitutive System x_c^-

SUBMITTER: de Baat A 

PROVIDER: S-EPMC10541846 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature