Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection.

ABSTRACT: The immune system is coordinated by an intricate network of stimulatory and inhibitory circuits that regulate host responses against endogenous and exogenous insults. Disruption of these safeguard and homeostatic mechanisms can lead to unpredictable inflammatory and autoimmune responses, whereas deficiency of immune stimulatory pathways may orchestrate immunosuppressive programs that contribute to perpetuate chronic infections, but also influence cancer development and progression. Glycans have emerged as essential components of homeostatic circuits, acting as fine-tuners of immunological responses and potential molecular targets for manipulation of immune tolerance and activation in a wide range of pathologic settings. Cell surface glycans, present in cells, tissues and the extracellular

SUBMITTER: Pinho SS 

PROVIDER: S-EPMC10541879 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature