Intestinal disturbances associated with mortality of children with complicated severe malnutrition.

ABSTRACT:

Background

Children admitted to hospital with complicated severe malnutrition (CSM) have high mortality despite compliance with standard WHO management guidelines. Limited data suggests a relationship between intestinal dysfunction and poor prognosis in CSM, but this has not been explicitly studied. This study aimed to evaluate the role of intestinal disturbances in CSM mortality.

Methods

A case-control study nested within a randomized control trial was conducted among children hospitalized with CSM in Kenya and Malawi. Children who died (cases, n = 68) were compared with those who were discharged, propensity matched to the cases on age, HIV and nutritional status (controls, n = 68) on fecal metabolomics that targeted about 70 commonly measured metabolites, and enteropathy m

SUBMITTER: Wen B 

PROVIDER: S-EPMC10541881 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature