Electric field promotes dermal fibroblast transdifferentiation through activation of RhoA/ROCK1 pathway.

ABSTRACT: With the increased incidence of age-related and lifestyle-related diseases, chronic wounds are sweeping the world, where recent studies reveal that dysfunction of fibroblast plays an indispensable role. Endogenous electric field (EF) generated by skin wound disrupting an epithelial layer has been used as an alternative clinical treatment in chronic wound by modulating cellular behaviours, including fibroblasts transdifferentiation. Although many molecules and signaling pathways have been reported associated with fibroblasts transdifferentiation, studies investigating how the electric field affects the cellular pathways have been limited. For this purpose, a model of electric field treatment in vitro was established, where cells were randomly divided into control and electrified grou

SUBMITTER: Wang W 

PROVIDER: S-EPMC10542021 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature