Reappraisal of intra-abdominal candidiasis: insights from peritoneal fluid analysis.

ABSTRACT:

Background

The understanding of high mortality associated with intra-abdominal candidiasis (IAC) remains limited. While Candida is considered a harmless colonizer in the digestive tract, its role as a true pathogen in IAC is still debated. Evidence regarding Candida virulence in the human peritoneal fluid are lacking. We hypothesized that during IAC, Candida albicans develops virulence factors to survive to new environmental conditions. The objective of this observational exploratory monocentric study is to investigate the influence of peritoneal fluid (PF) on the expression of C. albicans virulence using a multimodal approach.

Materials and methods

A standardized inoculum of a C. albicans (3.10⁶ UFC/mL) reference strain (SC5314) was introduced in vitro into vario

SUBMITTER: Novy E 

PROVIDER: S-EPMC10542081 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature