Occipital hypometabolism is a risk factor for conversion to Parkinson's disease in isolated REM sleep behaviour disorder.

ABSTRACT:

Purpose

Isolated REM sleep behaviour disorder (iRBD) patients are at high risk of developing clinical syndromes of the α-synuclein spectrum. Progression markers are needed to determine the neurodegenerative changes and to predict their conversion. Brain imaging with ¹⁸F-FDG PET in iRBD is promising, but longitudinal studies are scarce. We investigated the regional brain changes in iRBD over time, related to phenoconversion.

Methods

Twenty iRBD patients underwent two consecutive ¹⁸F-FDG PET brain scans and clinical assessments (3.7 ± 0.6 years apart). Seventeen patients also underwent ¹²³I-MIBG and ¹²³I-FP-CIT SPECT scans at baseline. Four subjects phenoconverted to Parkinson's disease (PD) during follow-up. ¹⁸F-FDG PET s

SUBMITTER: Carli G 

PROVIDER: S-EPMC10542098 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature