Low Shear in Short-Term Impacts Endothelial Cell Traction and Alignment in Long-Term.

ABSTRACT: Within the vascular system, endothelial cells (ECs) are exposed to fluid shear stress (FSS), a mechanical force exerted by blood flow that is critical for regulating cellular tension and maintaining vascular homeostasis. The way ECs react to FSS varies significantly; while high, laminar FSS supports vasodilation and suppresses inflammation, low or disturbed FSS can lead to endothelial dysfunction and increase the risk of cardiovascular diseases. Yet, the adaptation of ECs to dynamically varying FSS remains poorly understood. This study focuses on the dynamic responses of ECs to brief periods of low FSS, examining its impact on endothelial traction-a measure of cellular tension that plays a crucial role in how endothelial cells respond to mechanical stimuli. By integrating traction force mi

SUBMITTER: Chandurkar MK 

PROVIDER: S-EPMC10542130 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature