Diverse domain architectures of CheA histidine kinase, a central component of bacterial and archaeal chemosensory systems.

ABSTRACT: Chemosensory systems in bacteria and archaea are complex, multi-protein pathways that enable rapid cellular responses to environmental changes. The CheA histidine kinase is a central component of chemosensory systems. In contrast to other histidine kinases, it lacks a sensor (input) domain and utilizes dedicated chemoreceptors for sensing. CheA is a multi-domain protein; in model organisms as diverse as Escherichia coli and Bacillus subtilis, it contains five single-copy domains. Deviations from this canonical domain architecture have been reported, however, a broad genome-wide analysis of CheA diversity is lacking. Here, we present results of a genomic survey of CheA domain composition carried out using an unbiased set of thousands of CheA sequences from bacteria and archaea

SUBMITTER: Berry MA 

PROVIDER: S-EPMC10542144 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature