Integrating plasma proteomes with genome-wide association data for causal protein identification in multiple myeloma.

ABSTRACT:

Background

Multiple myeloma (MM) is a severely debilitating and fatal B-cell neoplastic disease. The discovery of disease-associated proteins with causal genetic evidence offers a chance to uncover novel therapeutic targets.

Methods

First, we comprehensively investigated the causal association between 2994 proteins and MM through two-sample mendelian randomization (MR) analysis using summary-level data from public genome-wide association studies of plasma proteome (N = 3301 healthy individuals) and MM (598 cases and 180,756 controls). Sensitivity analyses were performed for these identified causal proteins. Furthermore, we pursued the exploration of enriched biological pathways, prioritized the therapeutic proteins, and evaluated their druggability using the KEGG pathway ana

SUBMITTER: Wang Q 

PROVIDER: S-EPMC10542236 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature