Glucose-lowering effects of a synbiotic combination containing Pediococcus acidilactici in C. elegans and mice.

ABSTRACT:

Aims/hypothesis

Modulation of gut microbiota has emerged as a promising strategy to treat or prevent the development of different metabolic diseases, including type 2 diabetes and obesity. Previous data from our group suggest that the strain Pediococcus acidilactici CECT9879 (pA1c) could be an effective probiotic for regulating glucose metabolism. Hence, the objectives of this study were to verify the effectiveness of pA1c on glycaemic regulation in diet-induced obese mice and to evaluate whether the combination of pA1c with other normoglycaemic ingredients, such as chromium picolinate (PC) and oat β-glucans (BGC), could increase the efficacy of this probiotic on the regulation of glucose and lipid metabolism.

Methods

Caenorhabditis elegans was used as a screening model to d

SUBMITTER: Yavorov-Dayliev D 

PROVIDER: S-EPMC10542285 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature