Validation of quantitative assessment of florbetaben PET scans as an adjunct to the visual assessment across 15 software methods.

ABSTRACT:

Purpose

Amyloid positron emission tomography (PET) with [¹⁸F]florbetaben (FBB) is an established tool for detecting Aβ deposition in the brain in vivo based on visual assessment of PET scans. Quantitative measures are commonly used in the research context and allow continuous measurement of amyloid burden. The aim of this study was to demonstrate the robustness of FBB PET quantification.

Methods

This is a retrospective analysis of FBB PET images from 589 subjects. PET scans were quantified with 15 analytical methods using nine software packages (MIMneuro, Hermes BRASS, Neurocloud, Neurology Toolkit, statistical parametric mapping (SPM8), PMOD Neuro, CapAIBL, non-negative matrix factorization (NMF), Amyloid^IQ) that used several metrics to estimate Aβ loa

SUBMITTER: Jovalekic A 

PROVIDER: S-EPMC10542295 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature