Localized conditional induction of brain arteriovenous malformations in a mouse model of hereditary hemorrhagic telangiectasia.

ABSTRACT:

Background

Longitudinal mouse models of brain arteriovenous malformations (AVMs) are crucial for developing novel therapeutics and pathobiological mechanism discovery underlying brain AVM progression and rupture. The sustainability of existing mouse models is limited by ubiquitous Cre activation, which is associated with lethal hemorrhages resulting from AVM formation in visceral organs. To overcome this condition, we developed a novel experimental mouse model of hereditary hemorrhagic telangiectasia (HHT) with CreER-mediated specific, localized induction of brain AVMs.

Methods

Hydroxytamoxifen (4-OHT) was stereotactically delivered into the striatum, parietal cortex, or cerebellum of R26^CreER; Alk1^2f/2f (Alk1-iKO) littermates. Mice were evaluated for v

SUBMITTER: Scherschinski L 

PROVIDER: S-EPMC10542309 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature