Chromosome-level reference genome for North American bison (Bison bison) and variant database aids in identifying albino mutation.

ABSTRACT: We developed a highly contiguous chromosome-level reference genome for North American bison to provide a platform to evaluate the conservation, ecological, evolutionary, and population genomics of this species. Generated from a F1 hybrid between a North American bison dam and a domestic cattle bull, completeness and contiguity exceed that of other published bison genome assemblies. To demonstrate the utility for genome-wide variant frequency estimation, we compiled a genomic variant database consisting of 3 true albino bison and 44 wild-type pelage color bison. Through the examination of genomic variants fixed in the albino cohort and absent in the controls, we identified a nonsynonymous single nucleotide polymorphism (SNP) mutation on chromosome 29 in exon 3 of the tyrosinase gene (c.1114

SUBMITTER: Stroupe S 

PROVIDER: S-EPMC10542314 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature