The simplified Kirchhoff network model (SKNM): a cell-based reaction-diffusion model of excitable tissue.

ABSTRACT: Cell-based models of excitable tissues offer the advantage of cell-level precision, which cannot be achieved using traditional homogenized electrophysiological models. However, this enhanced accuracy comes at the cost of increased computational demands, necessitating the development of efficient cell-based models. The widely-accepted bidomain model serves as the standard in computational cardiac electrophysiology, and under certain anisotropy ratio conditions, it is well known that it can be reduced to the simpler monodomain model. Recently, the Kirchhoff Network Model (KNM) was developed as a cell-based counterpart to the bidomain model. In this paper, we aim to demonstrate that KNM can be simplified using the same steps employed to derive the monodomain model from the bidomain model. We

SUBMITTER: Jæger KH 

PROVIDER: S-EPMC10542379 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature