Altered gut microbiota and metabolites in untreated myasthenia gravis patients.

ABSTRACT:

Objective

The homeostasis of the immune system is influenced by the gut microbiota. Previous studies have reported dysbiosis in the gut microbiota of myasthenia gravis (MG) patients. To investigate potential alterations in gut microbiota and metabolites in newly diagnosed and untreated MG patients, we conducted a case-control study.

Methods

Fecal samples were collected from 11 newly diagnosed and untreated MG patients as well as 11 age-and sex-matched healthy controls. These samples underwent analysis for gut microbiota using 16S ribosomal RNA (rRNA) gene sequencing, while fecal metabolome was analyzed using liquid chromatography-electrospray tandem mass spectrometry system (LC-ESI-MS/MS).

Results

The microbial community richness (observed species) and diversity (Shan

SUBMITTER: Ding XJ 

PROVIDER: S-EPMC10542407 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature