The gene expression signature of electrical stimulation in the human brain.

ABSTRACT: Direct electrical stimulation has been used for decades as a gold standard clinical tool to map cognitive function in neurosurgery patients^1-8. However, the molecular impact of electrical stimulation in the human brain is unknown. Here, using state-of-the-art transcriptomic and epigenomic sequencing techniques, we define the molecular changes in bulk tissue and at the single-cell level in the human cerebral cortex following direct electrical stimulation of the anterior temporal lobe in patients undergoing neurosurgery. Direct electrical stimulation surprisingly had a robust and consistent impact on the expression of genes related to microglia-specific cytokine activity, an effect that was replicated in mice. Using a newly developed deep learning computational tool, we further de

SUBMITTER: Chatterjee S 

PROVIDER: S-EPMC10542502 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature