Gene-by-environment interactions influence the fitness cost of gene copy-number variation in yeast.

ABSTRACT: Variation in gene copy number can alter gene expression and influence downstream phenotypes; thus copy-number variation provides a route for rapid evolution if the benefits outweigh the cost. We recently showed that genetic background significantly influences how yeast cells respond to gene overexpression, revealing that the fitness costs of copy-number variation can vary substantially with genetic background in a common-garden environment. But the interplay between copy-number variation tolerance and environment remains unexplored on a genomic scale. Here, we measured the tolerance to gene overexpression in four genetically distinct Saccharomyces cerevisiae strains grown under sodium chloride stress. Overexpressed genes that are commonly deleterious during sodium chloride stress recapitul

SUBMITTER: Robinson D 

PROVIDER: S-EPMC10542507 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature