Construction and reconfiguration of dynamic DNA origami assemblies with coiled-coil patches and patterns.

ABSTRACT: DNA origami nanodevices achieve programmable structure and tunable mechanical and dynamic properties by leveraging the sequence specific interactions of nucleic acids. Previous advances have also established DNA origami as a useful building block to make well-defined micron-scale structures through hierarchical self-assembly, but these efforts have largely leveraged the structural features of DNA origami. The tunable dynamic and mechanical properties also provide an opportunity to make assemblies with adaptive structure and properties. Here we report the integration of DNA origami hinge nanodevices and coiled-coil peptides into hybrid reconfigurable assemblies. With the same dynamic device and peptide interaction, we make multiple higher order assemblies by organizing clusters of peptides

SUBMITTER: Teng T 

PROVIDER: S-EPMC10542533 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature