Multi-omics analysis reveals substantial linkages between the oral-gut microbiomes and inflamm-aging molecules in elderly pigs.

ABSTRACT:

Introduction

The accelerated aging of the global population has emerged as a critical public health concern, with increasing recognition of the influential role played by the microbiome in shaping host well-being. Nonetheless, there remains a dearth of understanding regarding the functional alterations occurring within the microbiota and their intricate interactions with metabolic pathways across various stages of aging.

Methods

This study employed a comprehensive metagenomic analysis encompassing saliva and stool samples obtained from 45 pigs representing three distinct age groups, alongside serum metabolomics and lipidomics profiling.

Results

Our findings unveiled discernible modifications in the gut and oral microbiomes, serum metabolome, and lipidome at each age s

SUBMITTER: Qiao C 

PROVIDER: S-EPMC10542583 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature