Predicting Blomia tropicalis allergens using a multiomics approach.

ABSTRACT:

Background

The domestic mite Blomia tropicalis is a major source of allergens in tropical and subtropical regions. Despite its great medical importance, the allergome of this mite has not been sufficiently studied. Only 14 allergen groups have been identified in B. tropicalis thus far, even though early radioimmunoelectrophoresis techniques (27 uncharacterized allergen complexes) and comparative data based on 40 allergen groups officially recognized by the World Health Organization (WHO)/IUIS in domestic astigmatid mites suggest the presence of a large set of additional allergens.

Methods

Here, we employ a multiomics approach to assess the allergome of B. tropicalis using genomic and transcriptomic sequence data and perform highly sensitive protein abundance quantification.<

SUBMITTER: Hubert J 

PROVIDER: S-EPMC10542617 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature