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John squire and endothelial glycocalyx structure: an unfinished story.


ABSTRACT: John Squire did not only produce leading works in the muscle field, he also significantly contributed to the vascular permeability field by ultrastructural analysis of the endothelial glycocalyx. Presented here is a review of his involvement in the field by his main collaborator C.C. Michel and his last postdoctoral researcher KP Arkill. We end on a reinterpretation of his work that arguably links to our current understanding of endothelial glycocalyx structure and composition predicting 6 glycosaminoglycans fibres per syndecan core protein, only achieved in the endothelium by dimerization.

SUBMITTER: Arkill KP 

PROVIDER: S-EPMC10542707 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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John squire and endothelial glycocalyx structure: an unfinished story.

Arkill Kenton P KP   Michel C Charles CC   Rider Elizabeth V M EVM   Wood Elise A EA   Small Mathew O MO   Brown Jennifer L E JLE   Kinnaird Abigail L AL  

Journal of muscle research and cell motility 20221019 3


John Squire did not only produce leading works in the muscle field, he also significantly contributed to the vascular permeability field by ultrastructural analysis of the endothelial glycocalyx. Presented here is a review of his involvement in the field by his main collaborator C.C. Michel and his last postdoctoral researcher KP Arkill. We end on a reinterpretation of his work that arguably links to our current understanding of endothelial glycocalyx structure and composition predicting 6 glyco  ...[more]

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