Transcriptome-wide association study-derived genes as potential visceral adipose tissue-specific targets for type 2 diabetes.

ABSTRACT:

Aims/hypothesis

This study aimed to assess the causal relationship between visceral obesity and type 2 diabetes and subsequently to screen visceral adipose tissue (VAT)-specific targets for type 2 diabetes.

Methods

We examined the causal relationship between VAT and type 2 diabetes using bidirectional Mendelian randomisation (MR) followed by multivariable MR. We conducted a transcriptome-wide association study (TWAS) leveraging prediction models and a large-scale type 2 diabetes genome-wide association study (74,124 cases and 824,006 controls) to identify candidate genes in VAT and used summary-data-based MR (SMR) and co-localisation analysis to map causal genes. We performed enrichment and single-cell RNA-seq analyses to determine the cell-specific localisation of the TWAS-

SUBMITTER: Tang H 

PROVIDER: S-EPMC10542736 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature