Tle4 controls both developmental acquisition and early post-natal maturation of corticothalamic projection neuron identity.

ABSTRACT: Identities of distinct neuron subtypes are specified during embryonic development, then maintained during post-natal maturation. In cerebral cortex, mechanisms controlling early acquisition of neuron-subtype identities have become increasingly understood. However, mechanisms controlling neuron-subtype identity stability during post-natal maturation are largely unexplored. We identify that Tle4 is required for both early acquisition and post-natal stability of corticothalamic neuron-subtype identity. Embryonically, Tle4 promotes acquisition of corticothalamic identity and blocks emergence of core characteristics of subcerebral/corticospinal projection neuron identity, including gene expression and connectivity. During the first post-natal week, when corticothalamic innervation is ongoing, T

SUBMITTER: Galazo MJ 

PROVIDER: S-EPMC10542749 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature