IFNγ-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regeneration.

ABSTRACT: The influence of aging on intestinal stem cells and their niche can explain underlying causes for perturbation in their function observed during aging. Molecular mechanisms for such a decrease in the functionality of intestinal stem cells during aging remain largely undetermined. Using transcriptome-wide approaches, our study demonstrates that aging intestinal stem cells strongly upregulate antigen presenting pathway genes and over-express secretory lineage marker genes resulting in lineage skewed differentiation into the secretory lineage and strong upregulation of MHC class II antigens in the aged intestinal epithelium. Mechanistically, we identified an increase in proinflammatory cells in the lamina propria as the main source of elevated interferon gamma (IFNγ) in the aged intestine, th

SUBMITTER: Omrani O 

PROVIDER: S-EPMC10542816 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature