Effect of recombination on genetic diversity of Caenorhabditis elegans.

ABSTRACT: Greater molecular divergence and genetic diversity are present in regions of high recombination in many species. Studies describing the correlation between variant abundance and recombination rate have long focused on recombination in the context of linked selection models, whereby interference between linked sites under positive or negative selection reduces genetic diversity in regions of low recombination. Here, we show that indels, especially those of intermediate sizes, are enriched relative to single nucleotide polymorphisms in regions of high recombination in C. elegans. To explain this phenomenon, we reintroduce an alternative model that emphasizes the mutagenic effect of recombination. To extend the analysis, we examine the variants with a phylogenetic context and discuss how diff

SUBMITTER: Hwang HY 

PROVIDER: S-EPMC10542817 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature