Liver metastasis affects progression pattern during immune checkpoint inhibitors monotherapy in gastric cancer.

ABSTRACT:

Introduction

The efficacy of immune checkpoint inhibitors (ICIs) is heterogeneous at each metastatic site, and tumor progression pattern is associated with survival; however, it remains unclear in gastric cancer (GC). Therefore, we aimed to clarify the progression pattern in response to ICIs in patients with GC, and we analyzed its mechanism focusing on the intratumoral immune cells.

Methods

Patients who received ICIs were retrospectively classified into non-systemic and systemic progression groups based on their radiological assessments. Moreover, the best percentage change in target lesions from each organ was compared.

Results

Among 148 patients, the non-systemic progression group showed a significant improvement in overall survival (OS) compared with the systemic

SUBMITTER: Motoo I 

PROVIDER: S-EPMC10542891 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature