Gene regulatory Networks Reveal Sex Difference in Lung Adenocarcinoma.

ABSTRACT: Lung adenocarcinoma (LUAD) has been observed to have significant sex differences in incidence, prognosis, and response to therapy. However, the molecular mechanisms responsible for these disparities have not been investigated extensively. Sample-specific gene regulatory network methods were used to analyze RNA sequencing data from non-cancerous human lung samples from The Genotype Tissue Expression Project (GTEx) and lung adenocarcinoma primary tumor samples from The Cancer Genome Atlas (TCGA); results were validated on independent data. We observe that genes associated with key biological pathways including cell proliferation, immune response and drug metabolism are differentially regulated between males and females in both healthy lung tissue, as well as in tumor, and that these regulato

SUBMITTER: Saha E 

PROVIDER: S-EPMC10543009 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature