Associations between depression symptom burden and delirium risk: a prospective cohort study.

ABSTRACT:

Background and objectives

Delirium and depression are increasingly common in aging. There is considerable clinical overlap, including shared symptoms and comorbid conditions, including Alzheimer's disease (AD), functional decline, and mortality. Despite this, the long-term relationship between depression and delirium remains unclear. This study assessed the associations of depression symptom burden and its trajectory with delirium risk in a 12-year prospective study of older individuals during hospitalization.

Research design and methods

319,141 UK biobank participants between 2006-2010 (mean 58y [range 37-74, SD=8], 54% female) reported frequency (0-3) of four depressive symptoms (mood, disinterest, tenseness, or lethargy) in the preceding 2 weeks, and aggregated into a dep

SUBMITTER: Gaba A 

PROVIDER: S-EPMC10543040 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature