The need for hemispheric separation in pairwise structural disconnection studies.

ABSTRACT: The development of new approaches indirectly measuring the structural disconnectome has recently led to an increase in studies investigating pairwise structural disconnections following brain damage. Previous studies jointly analyzed patients with left hemispheric and patients with right hemispheric lesions when investigating a behavior of interest. An alternative approach would be to perform analyses separated by hemisphere, which has been applied in only a minority of studies to date. The present simulation study investigated whether joint or separate analyses (or both equally) are appropriate to reveal the ground truth disconnections. In fact, both approaches resulted in very different patterns of disconnection. In contrast to analyses separated by hemisphere, joint analyses introduced

SUBMITTER: Rohrig L 

PROVIDER: S-EPMC10543104 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature