Single-subject cortical morphological brain networks across the adult lifespan.

ABSTRACT: Age-related changes in focal cortical morphology have been well documented in previous literature; however, how interregional coordination patterns of the focal cortical morphology reorganize with advancing age is not well established. In this study, we performed a comprehensive analysis of the topological changes in single-subject morphological brain networks across the adult lifespan. Specifically, we constructed four types of single-subject morphological brain networks for 650 participants (aged from 18 to 88 years old), and characterized their topological organization using graph-based network measures. Age-related changes in the network measures were examined via linear, quadratic, and cubic models. We found profound age-related changes in global small-world attributes and efficiency,

SUBMITTER: Ruan J 

PROVIDER: S-EPMC10543107 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature