Mapping the macrostructure and microstructure of the in vivo human hippocampus using diffusion MRI.

ABSTRACT: The hippocampus is classically divided into mesoscopic subfields which contain varying microstructure that contribute to their unique functional roles. It has been challenging to characterize this microstructure with current magnetic resonance based neuroimaging techniques. In this work, we used diffusion magnetic resonance imaging (dMRI) and a novel surface-based approach in the hippocampus which revealed distinct microstructural distributions of neurite density and dispersion, T1w/T2w ratio as a proxy for myelin content, fractional anisotropy, and mean diffusivity. We used the neurite orientation dispersion and density imaging (NODDI) model optimized for grey matter diffusivity to characterize neurite density and dispersion. We found that neurite dispersion was highest in the cornu ammon

SUBMITTER: Karat BG 

PROVIDER: S-EPMC10543110 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature