Association between gene expression and functional-metabolic architecture in Parkinson's disease.

ABSTRACT: Gene expression plays a critical role in the pathogenesis of Parkinson's disease (PD). How gene expression profiles are correlated with functional-metabolic architecture remains obscure. We enrolled 34 PD patients and 25 age-and-sex-matched healthy controls for simultaneous ¹⁸ F-FDG-PET/functional MRI scanning during resting state. We investigated the functional gradients and the ratio of standard uptake value. Principal component analysis was used to further combine the functional gradients and glucose metabolism into functional-metabolic architecture. Using partial least squares (PLS) regression, we introduced the transcriptomic data from the Allen Institute of Brain Sciences to identify gene expression patterns underlying the affected functional-metabolic architecture in PD.

SUBMITTER: Zang Z 

PROVIDER: S-EPMC10543112 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature