Preterm-birth alters the development of nodal clustering and neural connection pattern in brain structural network at term-equivalent age.

ABSTRACT: Preterm-born neonates are prone to impaired neurodevelopment that may be associated with disrupted whole-brain structural connectivity. The present study aimed to investigate the longitudinal developmental pattern of the structural network from preterm birth to term-equivalent age (TEA), and identify how prematurity influences the network topological organization and properties of local brain regions. Multi-shell diffusion-weighted MRI of 28 preterm-born scanned a short time after birth (PB-AB) and at TEA (PB-TEA), and 28 matched term-born (TB) neonates in the Developing Human Connectome Project (dHCP) were used to construct structural networks through constrained spherical deconvolution tractography. Structural network development from preterm birth to TEA showed reduced shortest path len

SUBMITTER: Zheng W 

PROVIDER: S-EPMC10543115 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature