JNKs protect from cholestatic liver disease progression by modulating Apelin signalling.

ABSTRACT:

Background & aims

Cholestatic liver injury is associated with c-Jun N-terminal kinases (JNK) activation in distinct cell types. Its hepatocyte-specific function during cholestasis, however, has not yet been established. Therefore, in our present study, we investigated the role of JNK1/2 during cholestasis and dissected its hepatocyte-specific function.

Methods

A cohort of patients with primary biliary cholangitis (n = 29) and primary sclerosing cholangitis (n = 37) was examined. Wild-type, hepatocyte-specific knockout mice for Jnk2 (Jnk2^Δhepa) or Jnk1 and Jnk2 (Jnk1^Δhepa/2^Δhepa) were generated. Mice were subjected to bile duct ligation (BDL) or carbon tetrachloride (CCl₄

SUBMITTER: Mohamed MR 

PROVIDER: S-EPMC10543210 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature