Association between age at first birth and postpartum depression: A two-sample mendelian randomization analysis.

ABSTRACT:

Background

Previous observational research has documented an association between age at first childbirth (AFB) and postpartum depression (PPD). However, the causal relationship remains unclear. This study aimed to assess the causal effects of AFB on PPD using a two-sample Mendelian randomization (MR) analysis.

Methods

Three sets of instrumental variables were obtained from the United Kingdom Biobank (UK Biobank), Neale Lab consortium and a meta-analysis of genome-wide association studies (GWAS). Single-nucleotide polymorphisms (SNPs) associated with the PPD phenotype were obtained from the Finngen consortium, which included 13,657 cases and 236,178 controls. Inverse variance weighted (IVW), weighted median, weighted mode, and MR-Egger methods to evaluate causal effects. Hete

SUBMITTER: Ou Z 

PROVIDER: S-EPMC10543215 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature